By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)
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Additional resources for Advances in Topical Antifungal Therapy
We repeat clinical control weekly, while the microbiological examinations have been repeated at the end of therapy (3 weeks) and again 2 weeks after the interruption of treatment. Results The results at the end of the 3 weeks of therapy have been excellent; we noticed a significant improvement in all the clinical symptoms observed (erythema, exudation, soaking, scaling, vesciculation, itching and rhagados) except in two patients. We noticed moreover the disappearance of Candida from the treated zones.
Are neutrophils going to be able to ingest and kill such large fungal structures? Plempel, Germany: As a consequence of the ergosterol inhibition we see in Candida and in dermatophytes that there is distinct damage not only to the membrane but also on the cell wall. Cells which have had contact with an azole, are much better ingested by neutrophils and phagocytes than normal cells. In the case of the clumps, I think they are really difficult for the phagocytoses, but on the other hand these clumps are not infective.
Dermatophytes or yeasts) Diagnosis of infection with Malassezia furfur established by Wood's Light Criteria of exclusion from trial Negative mycological findings in the presence of positive clinical findings Topical or systemic antifungal treatment during 2 or 4 weeks prior to trial Concomitant treatment with corticosteroids Patients were admitted to the study only if positive findings upon direct microscopic examination of the wet smear were confirmed by positive cultural findings. Patients with negative mycological findings despite positive clinical findings were excluded.