Download Antioxidant and Redox Regulation of Genes by Chandan K. Sen, Lester Packer, Patrick A. Baeuerle PDF

By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle

This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in numerous sickness strategies. attainable recommendations to pharmacologically and/or nutritionally control such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox rules of mobile responses* scientific implications of redox signaling and antioxidant remedy

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2. Redox Regulation of Gene Expression 27 1995). , 1997). A biphasic regulation of calmodulin-dependent protein kinase II (CaMKII ce) by the nitric oxide donor spermine NONOate was observed in hippocampal granule cells consisting of a strong induction of the mRNA followed by a later dramatic reduction in levels (Johnston and Morris, 1995). , 1997). Although early studies reported a lack of antioxidant enzyme modulation by oxidative stress in mammalian cells, subsequent studies have revealed moderate modulation of these genes.

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