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By Ronald W. Estabrook and Paul Srere (Eds.)

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23. , Metzenberg, R. , and Cohen, P. , J. Biol. Chem. 236, 2229-2237 (1961). 23a. , and Cohen, P. , J. Biol. Chem. 253, 8337-8339 (1978). 24. Metzenberg, R. , Hall, L. , and Cohen, P. , J . Biol. Chem. 229, 1019-1025 (1957). 25. ,Eur. J. Biochem. 7, 119-127 (1968). 26. , Biochem. J. 127, 503-508 (1972). 27. , and Jones, M. , Arch. Biochem. Biophys. 175, 270-278 (1976). 28. ,Eur. J. Biochem. 85, 373-383 (1978). 29. Elliott, K. R. , and Tipton, K. , FEBS Lett. 37, 7 9 - 8 1 (1973). 30. , and Cohen, P.

Hydrazide-treated animals that exhibited glutathionuria for 1 hour showed no glutathionuria several hours later, indicating that the phe­ nomenon is reversible; and microscopic studies of the kidneys of ani­ mals given these hydrazides showed no evidence of cellular damage. Mice given the inhibitor alone showed a slight decrease of liver glutathione and a much greater decrease in the glutathione level of the kidney. When an inhibitor of glutathione synthesis (prothionine sul­ foximine) was given, there was a marked decrease in the levels of glutathione in the kidney and a smaller decline of liver glutathione.

D. Thesis, University of Wisconsin, Madison, 1974. 30b. Strahler, J. , Fed. Proc, Fed. Am. Soc. Exp. Biol. 34, 604 (1975). 31. , in "The Urea Cycle" (S. Grisolia, R. Baguena, and F. ), pp. 133-142. Wiley, New York, 1976. 32. Fahien, L. , Schooler, J. , Gehred, G. , and Cohen, P. , J . Biol. Chem. 239, 1935-1941 (1964). 33. Metzenberg, R. , and Cohen, P. , J. Biol. Chem. 233, 1560-1564 (1958). 34. Fahien, L. , and Cohen, P. , J. Biol. Chem. 239, 1925-1934 (1964). 35. Elliott, K. R. F , and Tipton, K.

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