Download Cannabinoid Modulation of Emotion, Memory, and Motivation by Patrizia Campolongo, Liana Fattore PDF

By Patrizia Campolongo, Liana Fattore

The endocannabinoid method comprises cannabinoid receptors, their endogenous lipid ligands (endocannabinoids) and the enzymatic equipment for his or her synthesis and degradation. within the mind, endocannabinoids control ion channel task and neurotransmitter liberate and thereby give a contribution to varied points of mind functionality, together with reminiscence, gift and feelings. Their skill to modulate synaptic efficacy has a variety of sensible effects and gives detailed healing percentages. extraordinary advances were made within the figuring out of the function of endocannabinoids within the legislation of the emotional mind over the last few years. although, a complete e-book encompassing most of these features continues to be missing. The ebook will offer an summary of the function performed by means of the endocannabinoid process within the legislation of emotional tactics with specific emphasis at the modulation of reminiscence and present for emotionally arousing occasions and for the legislation of motivational elements in hashish use.

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Data was published by [95] in Neurosci Biobehav Rev) a reduction in the stress-induced increase in corticosterone levels. g. the hippocampal formation). Hence, the reduction in hypothalamic-pituitary-adrenal axis activity may prevent the enhancing or the impairing effects of stress on emotional memory. In support, it has been shown that CB1 receptor agonists decrease the excitability of projection neurons in the rat basolateral amygdala [108]. Several studies have shown that activating CB1 receptors or increasing AEA signaling, prevents some of the effects of stress in the 38 I.

2011;13(1):22–37. 142. Millan MJ. The neurobiology and control of anxious states. Prog Neurobiol. 2003;70(2):83– 244. 143. Myhrer T. Neurotransmitter systems involved in learning and memory in the rat: a metaanalysis based on studies of four behavioral tasks. Brain Res Brain Res Rev. 2003;41(2– 3):268–87. 144. Metna-Laurent M, Soria-Gómez E, Verrier D, Conforzi M, Jego P, Lafenetre P, Marsicano G. Bimodal control of fear-coping strategies by CB1 cannabinoid receptors. J Neurosci. 2012;32(21):7109–18.

2 mg/kg) impaired the performance of rats in the social and object recognition task [63]. We found that WIN55,212–2 (5 µg/side) impaired acquisition and retrieval of social recognition when microinjected into the hippocampus and impaired acquisition when microinjected into the medial amygdala [64]. 1 for a general summary of the pharmacological studies examining the effects of exogenous cannabinoids on non-aversive memory paradigms. Aversive Memory Tasks Water maze procedures which focus on spatial memory have been extensively used to test the effects of cannabinoids on different stages of hippocampal-dependent 28 I.

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