By CIBA Foundation Symposium
Many alternative pathological stipulations are presently below research as healing ambitions of purines together with melanoma, cardiovascular stipulations, behavioural issues, irritation, immunoregulation, and neuroendocrine functionality. This ebook attracts jointly examine on all facets of P2 purinoceptors and discusses their use in numerous healing parts.
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Extra info for Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms
So overall in the brain there are about 50 times more P2Y, and related P2Y receptors than that class of P2X receptors. There is much less P2U receptor binding. There is a set of binding sites for a,[%methylene ATP in the brain (which we can measure by binding to brain membranes and which Geoff Burnstock and co-workers have seen by 30 Discussion autoradiography) that shows the pharmacology of certain subtypes of the P2X receptor such as P2X1 (Michel & Humphrey 1993). ) which do not respond to a,b-methylene ATP.
I find it increasingly hard to explain to others that we still use these to see what happens with our receptors. There’s a real need for radiolabelled antagonists that are stable. Burnsfock: You’re right; there really is a need for such compounds. Jacohson: We’ve seen that P2Y-radioligand binding reaches a peak within five minutes or so, and then beyond that we have diminishing returns. Have you seen that also in your studies with deoxyATPaS? Barnurd: No. Was that in divalent-cation free medium‘?
Arch Biochem Biophys 305:5&60 Williams M 1993 Purinergic drugs: opportunities in the 1990s. Drug Dev Res 28:438444 Woolridge S, van Helden D F 1990 Enhanced excitatory junction potentials in (mesenteric) arteries of the spontaneously hypertensive rat. Proc Austr Physiol Pharmacol SOC21:60P Yatani A, Tsuda Y, Akaike N, Brown AM 1982 Nanomolar concentrations of extracellular ATP activate membrane Ca channels in snail neurones. Nature 296: 169171 Young JZ 1988 Sympathetic innervation of the rectum and bladder of the skate and parallel effects of ATP and adrenalin.