By Gretchen M Lentz MD, Rogerio A. Lobo MD, David M Gershenson MD, Vern L. Katz MD
Previously edited by way of Drs. Droegemueller, Stenchever, Mishell & Herbst - this relied on and demonstrated reference presents entire, well timed, and straightforward entry to very important details at the scientific and surgical concerns affecting contemporary day-by-day gynecology perform. that includes the clean views of 4 new editors, in addition to new members, the textual content bargains functional, in-depth coverage...helpful illustrations - many new to this edition...and clinically orientated guidance...page after web page! Plus, entry the total contents on-line, absolutely searchable at www.compgyn.com - so that you can locate quickly solutions from an location.Access state of the art suggestions at the newest minimally invasive surgical techniques...the most up-to-date functions in diagnostic and interventional ultrasound...and many different crucial facets of modern day perform. entry clean perform views from 4 new editors and new individuals. successfully deal with the emotional facets of the distinctiveness with targeted new chapters overlaying rape * incest * and household violence, between others. Diagnose stipulations adequately with the visible relief of approximately 1,000 illustrations - together with greater than a hundred new full-color photos.Quickly locate the data you wish with uncomplicated good points together with key words, key issues, and using colour throughout.Exponentially strengthen your medical reference energy with entry to the total contents on-line - totally searchable - in addition to all the illustrations to be used in digital shows. stopover at www.compgyn.com for details.Presents the paintings of 4 new affiliate editors and plenty of new members who provide clean perform perspectives.Includes specified new chapters masking rape · incest · family violence · and different hugely emotional features of the specialty.Features greater than a hundred new full-color photographs that assist you determine lesions and interpret pathologic findings.Provides elevated fabric on menopause, reflecting the ever-increasing getting older sufferer inhabitants.
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Extra resources for Comprehensive Gynecology
In the RNA molecule, uracil (U) is substituted for thymine. When all segments of the message are covered, the amino acids are spliced together and the protein determined by the message is com-plete and free for use in the cell and for transport from the cell. Figure 2-1 schematically demonstrates this process. Figure 2-1 Schematic representation of polypeptide production from genetic message to final product. ) In its simplest form, a gene is a sequence of codons that, when transcribed and translated, will become a functional product.
Figure 2-12 Standard figures and nomenclature for a pedigree. ) Autosomal Dominant In an autosomal dominant mode of inheritance, only one copy of the mutated gene is required for expression of the trait, and the individual is said to be heterozygous for the trait. There are over 4000 known autosomal dominant conditions, and most occur in the heterozygous form in affected individuals. With a few exceptions, autosomal dominant Page 102 conditions occurring in the homozygous form (two copies of the affected gene) are rare, the phenotype is more severe, and are often lethal.
Conversely, a mutation at the end of the gene may result in a truncated but still translatable mRNA, leading to a partially functional gene product. Point mutations within the gene could result in an amino acid substitution, leading to different products with altered functions. Figure 2-3 demonstrates such an occurrence for sickle cell anemia caused by the substitution of a single base at a single point. The cystic fibrosis transmembrane conductance regulator (CFTR) gene is an example of a gene for which over 1000 mutations or alleles have been described to date.