Download Diabetes - Perspectives in Drug Therapy by Christina Schwanstecher, Mathias Schwanstecher (auth.), PDF

By Christina Schwanstecher, Mathias Schwanstecher (auth.), Mathias Schwanstecher (eds.)

Every five seconds somebody someplace is clinically determined with diabetes, and each 10 seconds a person dies of it. Even worse, world wide prevalence premiums nonetheless inexorably boost. therefore, it really is urgent to envisage the level of the diabetes challenge and make sure synergistic methods aiming in relief of its ghastly toll. The chapters of this booklet record state-of-the-art learn on molecular occasions in adiposity and kind 2 diabetes, hence beginning the way in which for cutting edge drug-based healing techniques. It addresses all those that desire to keep up a correspondence with contemporary advancements within the field.

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J Lipid Res 48:1905–1914 Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48:1270–1274 Griffin JM, Gilbert KM, Pumford NR (2000) Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice. Toxicol Sci 54:384–389 Targeting Type 2 Diabetes 25 Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.

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Metabolism 52:586–589 Bouhlel MA, Derudas B, Rigamonti E, Dievart R, Brozek J, Haulon S, Zawadzki C, Jude B, Torpier G, Marx N, Staels B, Chinetti-Gbaguidi G (2007) PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab 6:137–143 Breen DM, Giacca A (2010) Effects of insulin on the vasculature. Curr Vasc Pharmacol. Sep 1 [Epub ahead of print] Buettner C, Pocai A, Muse ED, Etgen AM, Myers MG Jr, Rossetti L (2006) Critical role of STAT3 in leptin’s metabolic actions.

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